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| CAS Number: | 2672512-44-4 |
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| Product Code: | ARL10119 |
| Molecular Formula/Molecular Weight: | / 1076.06 |
| Purity: | 99% |
| HSN Code: | 28012000 |
Note: For research use only, not for direct human use.*
| Pack Size | Unit Price | Stock in Mumbai- WH | Stock in Hyderabad- WH | Quantity |
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Description : MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively.
| Purity(HPLC) | min. 99% |
| Confirms Structure | NMR |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | -20°C |
| Storage Condition | Light, heat and moisture sensitive |
| Packaging and Container | Glass vial |
| Pictogram : |
MS432 is a proteolysis-targeting chimera (PROTAC) designed to degrade MEK1 and MEK2 proteins by recruiting the von Hippel-Lindau (VHL) ligase. Its application is as a tool in basic medical research for investigating the roles of MEK1/2 in cellular signaling pathways and as a component in cancer therapies to reduce cell proliferation. Specifically, it has shown promise in degrading MEK1/2 in cancer cells, leading to a reduction in cell growth and demonstrating potential in future cancer drug discovery.
This is a sample COA and may not represent a recently manufactured lot of the product.
